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Showing posts with label Clinical trial. Show all posts
Showing posts with label Clinical trial. Show all posts

Monday, December 19, 2011

Pioneering liver treatment cures British baby

Another breakthrough, a medical advancement...
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Posted: 16 November 2011


A group of cells was injected into a 8 year-old boy, saving him from acute liver failure. (AFP/Getty Images/Justin Sullivan)
LONDON: British doctors on Tuesday said they had cured a baby boy of a life-threatening liver disease using a pioneering treatment in which cells are injected into the abdomen.

The team from London's King's College Hospital treated eight-month old Iyaad Syed by injecting him with a group of cells, which acted as a temporary
liver while his real organ recovered from damage caused by a virus, BBC reported.

"This is the first time this treatment has been used to treat a child with acute liver failure," said professor Anil Dhawan, a liver specialist at the hospital.

"It's only a few months back when I first saw this child who was so sick requiring support on dialysis and a breathing machine.

"We think we have given him another chance of life and seeing him now six months down the road with nearly normal liver function is remarkable."

Syed would normally have been put on the transplant waiting list when his liver began to fail, but the hope now is that more cases will be cured using the new technique rather than relying on a scarce supply of donor organs.

Doctors injected liver cells which then processed toxins and produced proteins, fulfilling the role of a temporary liver while his own began to recover two weeks later.

The cells were treated with a chemical to prevent them from being destroyed by the youngster's immune system.

Iyaad's father, Jahangeer, called his son "a miracle boy", adding "it is brilliant and we are very proud of him."

The treatment's development now depends on an extensive clinical trial.

Andrew Langford, Chief Executive of the British Liver Trust, told the BBC: "The principle of this new technique is certainly ground-breaking and we would welcome the results of further clinical trials to see if it could become a standard treatment for both adults and children.

"Sadly, we have reached a breaking point with our transplant list in the UK, where approximately 100 people die waiting for a donor liver to become available each year."

-AFP/vl



Taken from ChannelNewsAsia.com; source article is below:
Pioneering liver treatment cures British baby


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Broken heart fix with stem cells

Posted: 15 November 2011

A model of a heart
PARIS: Stem cells from heart-attack patients helped improve blood-pumping ability and restore vitality in cardiac muscle, according to a small trial published on Monday.

It is the first time patients have been given an infusion of their own
cardiac stem cells in the aim of solving the impact of heart failure rather than simply treating the symptoms of it.

The findings are so promising that the study's chief investigator said a potential "revolution" was in the offing if larger trials succeeded.

Stem cells are infant cells that develop into the specialised tissues of the body.

They have sparked great excitement as they offer hopes of rebuilding organs damaged by disease or accident.

The new study, published online in The Lancet, tested cardiac stem cells on 16 patients who had been left gravely ill as a result of an acute myocardial infarction.

The index used for cardiac health is called the left ventricular ejection fraction (LVFV), which calculates the capacity of the left ventricle to expel blood in the space of a heartbeat.

For a person in normal health, the LVFV is 50 percent or higher.

Among the study patients, though, this had fallen to 40 percent or lower. At such a threshold, shortness of breath and fatigue are chronic and often disabling.

The stem cells were isolated from a coronary artery that had been removed when the patients underwent a coronary bypass.

Within four months of treatment, the LVFV rose by 8.5 percent and after a year by 12 percent - four times what the researchers had expected.

Scans of the patients' hearts also showed a reduction in the area of tissue that had been scarred by the infarction, a discovery that challenges conventional belief that once scarring occurs, heart tissue is permanently dead.

The volunteers also reported a substantial improvement in quality of life, and there were no significant side effects.

Seven patients with similar heart problems were enrolled as "controls", to serve as a comparison. There was no change in their LVFV, in scar tissue or in their quality of life.

"The results are striking," said lead investigator Roberto Bolli of the University of Louisville, Kentucky.

"While we do not know why the improvement occurs, we have no doubt now that 1/8LVFV 3/8 increased and scarring decreased.

"If these results hold up in future studies, I believe this could be the biggest revolution in cardiovascular medicine in my lifetime."

The team is seeking funding to launch a larger, or Phase II, trial - the second in the normal three-phase process of assessing a new treatment for safet and effectiveness.

Previous stem-cell work on heart damage has used cells harvested from bone marrow.

The interest in cardiac stem cells is that they are self-renewing, produce daughter cells and differentiate into all types of cells in the heart.

The results were presented concurrently at a meeting of the American Heart Association in Orlando, Florida.

-AFP/pn



Taken from ChannelNewsAsia.com; source article is below:
Broken heart fix with stem cells


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